Involvement of Multidrug Resistance-Associated Protein 1 in Intestinal Toxicity of Methotrexate
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چکیده
منابع مشابه
Transport of fluorescein methotrexate by multidrug resistance-associated protein 3 in IEC-6 cells.
The transport characteristics of fluorescein methotrexate (F-MTX) were studied by using the rat intestinal crypt cell line IEC-6. Enhanced accumulation of F-MTX at 4 degrees C suggests the existence of an active efflux system. MK-571, an inhibitor of the multidrug resistance-associated protein/ATP binding cassette C (MRP/ABCC) family, also enhanced the accumulation of F-MTX. Transcellular trans...
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Efflux transporters such as P-glycoprotein and multidrug resistance-associated proteins (MRPs) in the intestinal wall restrict intestinal drug transport. To overcome this limitation for enteral drug absorption, galenical targeting approaches have been proposed for site-specific luminal drug release in segments of the gut, where expression of the respective absorption-limiting transporter is min...
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ژورنال
عنوان ژورنال: Pharmaceutical Research
سال: 2009
ISSN: 0724-8741,1573-904X
DOI: 10.1007/s11095-009-9858-6